Cannabidiol (CBD) is one of the compounds found in cannabis plant that has been soaring in popularity lately due to its health benefits. When CBD is ingested it reacts with certain receptors of the endocannabinoid system (ECS) in the body and promotes therapeutic effects. CBD is widely used to treat pain, inflammation, stress, nausea, anxiety and sleep disorders.

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Should I be concerned about taking CBD along with other medication?

Yes! Any chemical compound is bound to react with another compound. CBD is generally considered safe for use and has little or no side effects. However, just like how stuff like grapefruit, alcohol and caffeine reacts with certain prescribed medication, CBD interacts with certain medication when used in high dose.

CBD’s interaction with the body’s Cytochrome P-450 System (CYP450):

The enzyme family CYP450 found in the liver is responsible for metabolizing 60% of drugs. Doctors consider the CPY450’s processing time while prescribing medication dosage. If more than one drug is ingested, the processing time of the medicine varies and alters the drug’s metabolizing rate. When CBD reacts with CYP enzymes, it could cause certain drug interactions.

Interaction between CBD and certain drugs:

  • Drugs that amplify risk of bleeding: CBD is found to amplify the effects of blood- thinning drugs. When the effects of the medication are prolonged, there arises risk of bleeding and hence careful monitoring is required.
  • Sedatives: CBD is well-known for its calming effects and used by those who have insomnia or other sleep disorders. When CBD is used in conjunction with sedatives, it produces an additive effect and the nature of negative effects are not yet clear.
  • Anti-seizure medication: Though CBD is effective in treating certain types of seizures, in certain cases low CBD doses will interact with p450 enzymes thereby increasing the concentration of norclobazam and clobazam. This results in more severe seizures.
  • Chemotherapy drugs: The accuracy of chemotherapy medication dosage is very essential as low dosage would be ineffective while high dosage is toxic. Though CBD helps with cancer, it shouldn’t be used in conjunction with chemotherapy medication.

Ways to take CBD:

There are different ways to ingest CBD and the metabolizing rate of drugs differs based on the type of ingestion method. CBD oils and tinctures, vapes and edibles could interact with certain other drugs. CBD topical are meant for external usage and don’t interact with other medication. The choice of ingestion method depends on the reason you are using CBD and preference.

Regular users of CBD have found it to be very beneficial. There’s no doubt regarding CBD’s effectiveness. However, you should exercise caution when you are using other prescription medication. Consult your doctor and discuss about possible drug interactions with CBD.